ANG 4102 – ASK1 Inhibitor

Apoptosis signal-regulating kinase 1 (ASK1) is a member of MAP kinase kinase kinase (MAP3K) family of protein kinases. In response to cellular stress, such as oxidative stress, it stimulates signal transduction pathways resulting in the activation of c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase. ASK1 has been found to be involved in several diseases, such as neurodegenerative diseases, diabetes and cardiovascular diseases. In contrast to p38 and JNK, which have important homeostatic roles, ASK1 is thought to be only activated in pathologic states, thus making it an attractive target to specifically interfere with pathologic, but not homeostatic signaling through the p38 MAPK and JNK signal transduction pathways. Angion has identified a promising proprietary lead series of potent small molecule ASK1 inhibitors, exemplified by ANG4102, and is evaluating their potential use in Acute Kidney Injury and Myocardial Infarction.