pipeline

ANG-3777

Mechanism of Action

ANG-3777, is potentially a first-in-class hepatocyte growth factor (HGF) mimetic. We engineered ANG-3777 to mimic the biological activity of HGF in activating critical pathways in the body’s natural organ repair process following an acute organ injury.

Clinical Trials

ANG-3070

Mechanism of Action

ANG-3070, is a highly selective, orally-bioavailable small molecule tyrosine kinase receptor inhibitor developed internally as a potential treatment for fibrotic diseases, particularly in the lung and kidney.

Clinical Trials

Preclinical Studies

• Lung Fibrosis
• Renal Disease and Fibrosis

ROCK2 INHIBITOR

Rho kinase (ROCK) signal transduction pathways are implicated in the development of fibrosis. Inhibition of the ROCK isoforms, ROCK1 and ROCK2, has shown promise in fibrosis; however, ROCK1 inhibition has been associated with inducing hypotension. Recent scientific work using specific genetic or pharmacological inhibition of ROCK2 indicates ROCK2 inhibition alone can result in anti-fibrotic activity without causing hypotension. These findings informed our strategy to develop ROCK2-specific inhibitors as a potential treatment of fibrosis.

Dual ROCK1/2 inhibitors have been shown to have problematic side effects including hypotension and vascular permeability. However, in vivo studies demonstrate our lead compound has more than five hundred-fold selectivity for ROCK2 versus ROCK1. We believe high selectivity for ROCK2 could translate into a product candidate with enhanced tolerability that may support long-term systemic use.

The initial focus for our ROCK2 program is expected to be on fibrotic indications such as chronic kidney disease, IPF and nonalcoholic steatohepatitis (NASH). Given the heterogeneity of these diseases, we believe development of this program will benefit from our precision medicine approach and use of established clinical biomarkers.