pipeline

ANG-3777 ANG-3777 ANG-3070 ROCK2

ANG-3777

Mechanism of Action

ANG-3777 is an HGF mimetic engineered to bind to the c-Met receptor and activate the pathways involved in tissue repair and complement the endogenous mismatch between HGF levels and c-Met expression after organ injury.

Clinical Trials

ANG-3070

Mechanism of Action

ANG-3070 is an orally-bioavailable small molecule exhibiting preferential activity against fibrokinases – molecular pathways associated with poor outcomes in fibrotic conditions.

Clinical Trials

Preclinical Studies

• Pulmonary Fibrosis
• Acute Colitis
• Renal Disease and Fibrosis

ROCK2 INHIBITOR

Mechanism of Action

An orally bioavailable small molecule ROCK2 inhibitor binding to serine/threonine kinase, which regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers, and focal adhesions.

Preclinical Studies

• Chronic Kidney Disease
• Biliary Sclerosis
• Nonalcoholic Steatohepatitis (NASH)